Thyroid and adrenal insufficiency is one of the main reasons behind low metabolic energy which can cause a wide variety of symptoms such as the following: 1.General: low body temperature,coldness, fatigue, weight gain(sometime loss) 2.Brain: depression, anxiety, memory issues, lack of focus and sleep issues 3.Immune system: Frequent infections or allergies 4.Musculosketal: fatigue, muscle or joint pains, headaches 5.Sexual: menstrual disorders, infertility, loss of libido 6.V